邢唷> KMJ欹'` 餜T,bjbjLULU72.?.? P,,,8d,D I:III9999999$!<h>b99ZIIZZ9:hhhZ 9hZ9hh39 @/`=溗,f\549:0I:5p>>h9>9IhJh<7#III99 ^IIII:ZZZZD D D DD D D $4L 齎u杒;Sf[OO R 0Fertil Steril 02005;84:662 71 Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia 蘏騰彇:gzz}v鵞gq4N奮諎寶鵞詋US(u鎉薳墍眡 US(uYNp戞]薳墍眡 TT擽(u YT鎉薳墍眡鎉薳墍眡 YNp戞]薳墍眡 籰梪7u'`yr裇'`1_緗莡剉觺済 Objective: To evaluate the effectiveness of L-carnitine (LC) or L-acetyl-carnitine (LAC) or combined LC and LAC treatment in improving semen kinetic parameters and the total oxyradical scavenging capacity in semen. 諎寶顅剉鵞詋纇KmUS靣O(u鎉薳墍眡 US靣O(uYNp戞]薳墍眡 NTT擽(u YT鎉薳墍眡鎉薳墍眡 YNp戞]薳墍眡 鵞籰梪孴瀀燫緗P[剉;m≧汻cpe孴緗瞞匭籗d'l鶺剉\O(uHe済0 Design: Placebo-controlled double-blind randomized trial. 緥筫Hh緥 g塠paBR鵞gq膥剉蘏騰彇:g諎寶 Setting: Andrology unit, Department of Internal Medicine, Polytechnic University of Marche, Italy. :W@ba'Y)R黤R褃b'Yf[;Sf[钀7u褃 Patient(s): Sixty infertile men, ages 20 to 40 years, with the following baseline sperm selection criteria: concentration >20 X 106/mL, sperm forward motility <50%, and normal sperm morphology >30%; 59 patients completed the study. 諎寶舥篘60 T N瞼舥篘t^劅20-40乗 w嵥Y緗P[纇Km剉ch髞\緩0R錘 NeQ h芉 緗P[Sm:N>20 X 106/mL 緗P[剉MRT;m≧噑 \嶯50% ;`;m≧噑>30% 59 T舥篘孾b哊,g諎寶0 Intervention(s): Patients underwent a double-blind therapy of LC 3 g/d, LAC 3, a combination of LC 2 g/d and LAC 1 g/d, or placebo. The study design was 1 month of run in, 6 months of therapy or placebo, and 3 months of follow-up evaluation. r^剺猚絜錘蘏騰剉b__ 舥篘 g(u鎉薳墍眡3g/)Y bYNp戞]薳墍眡3 g/d b YT鎉薳墍眡鎉薳墍眡2g/d YNp戞]薳墍眡1g/)Y 蹚L埢l梪b g(u塠paBR0xvz鰁魰耂燫諎寶MR1*Ng鄀o儎vm1g 6*Ng go/塠paBR Y燫3*Ng\PoT剉邖*g0 Main Outcome Measure(s): Variations in semen parame02:NPR& (  < B D F Z \ $ 胴陌販悅悅悅sgsgsgs\RI@h6Eh6E^Jh6Eha8^Jh6Eha85乛Jha85丆J\乤Jh6E5丆J\乤Jo(h:h:5丆J\乤Jo(h:h:5丆J\乤Jh:5丆J\乤Jo('h:h:CJKHOJQJ^JaJo('h:h:5丆JKHOJQJ^JaJ'h:h:CJKHOJQJ^JaJo($h:h:CJKHOJQJ^JaJ'h:h:CJKHOJQJ^JaJo(PR D F  8 : $&N $1$7$8$H$a$gd廭 $1$7$8$H$a$gd+u $1$7$8$H$a$gd齏 $d轧a$gd6E $d轧a$gd醨 $d轧a$gd: $1$7$8$H$a$gd: ,R,$ & 8   6 8 J L "$<>"$*,df庹幕豹φ摩煢鈽憳~wrwnwiwawnwnwh+uh+uH* h+uo(h+u hd o( h+uh+u$h齏ha8CJKHOJQJ^JaJ hw.^Jo( h齏^Jo( h+uh齏ha8 ha85乗hkqha85乗h6Eha8^J ha8^Jo(h6Eh6E^Jo(hkqha85乗乛Jo(hkqhkq5乗乛Jo(h6Eh6E^J h6E^Jo(&$BFLNRXZ\^`bdhjprxnp尜瘴涨吻握俏良复沾寨瘴ㄎ刚瘟刚握肝铡諝鷼枤x h廭^Jo(h廭h廭^Jo(h鰏ha85乗乛Jo(h廭 h廭h廭 ha85乗 h鰏^Jo( ha8H*h>0h+u h+uo( h+u^J h>0^Jo( ha8^Jo(ha8hkqha85乗乛Jo(hkqhkq5乗乛Jo( h+uh+u hd o(/ "0>HJTVZ`hjnrt|~"p"r""""""###(#.###$$%%x&z&`'b'镨鲠谟田嵊鎏秭田语田田迢碰炯痉惊L樱迢艤暦暦暦暦暦 hd h猽 hd ha8 h猽^Jo(h鰏ha85乗乛Jo( hd o(U h猽h猽 ha85乗 ha8^Jo( h{n^Jo( hp^Jo( h.s^Jo( h廭h廭 h廭^Jo(ha8 h廭o(:"##l())+ ,$,&,*,,,0,2,6,8,:,<,>,@,B,D,# "&dPgd縤n" $1$7$8$H$a$gd猽 $d轧a$gd醨ters used for patient selection, and variations in total oxyradical scavenging capacity of the seminal fluid. ;N亯觺済Km蠎纇Km舥篘剉緗P[耂pe孴緗瞞匭籗'l烺齹剉豐S0 Result(s): Sperm cell motility (total and forward, including kinetic features determined by computer-assisted sperm analysis) increased in patients to whom LAC was administered both alone or in combination with LC; combined LC _ LAC therapy led to a significant improvement of straight progressive velocity after 3 months. The total oxyradical scavenging capacity of the semen toward hydroxyl and peroxyl radicals also increased and was positively correlated with the improvement of kinetic features. Patients with lower baseline values of motility and total oxyradical scavenging capacity of the seminal fluid had a significantly higher probability of responding to the treatment. 觺済蟸(u梴:g纇Km鹼邁纇寶 US(u鎉薳墍眡bUS(uYNp戞]薳墍眡}6q龕齹衏貧緗P[剉;m≧汻 FOTT擽(u YT鎉薳墍眡鎉薳墍眡 YNp戞]薳墍眡 剉\O(uHe済>fWO嶯MR$N剉US(u0緗P[剉籗d'l鶺烺齹 sS籗d枱鶺"l'l鶺孴菑'lS"l鶺剉齹汻_N彇KN瀀燫 NN緗P[;m≧汻剉瀀燫ck鴙sQ0 諎寶w嵥Y鰁 ;m≧汻儚NO蔛籗d'l鶺烺齹儚頬剉剉 籰梪He済鬴f>f0 Conclusion(s): The administration of LC and LAC is effective in increasing sperm kinetic features in patients affected by idiopathic asthenozoospemia and improves the total oxyradical scavenging capacity of the seminal fluid in the same population. 觺簨 YT鎉薳墍眡鎉薳墍眡 YNp戞]薳墍眡 齹鬴f>f0W衏貧緗P[剉1_緗剉;m≧汻 瀀蹚緗P[剉籗d柧|瞞匭'l鶺剉齹汻0     b'F(H(l(r((()0)6)8)@)H)V)X))))))**l+n++++++++, ,",&,(,,,.,2,4,R,T,嘀拭姑姑裁搏欩豉豉绔挮拫劎|x|x|x|xh縤njh縤nU h萭^Jo( h.^Jo( hpW^Jo( ha85乗 hzha8ha8 ha8^Jo( h聗_^Jo(hj,hj,^Jo( hj,^Jo(ht Oh(5乛Jo(h(h(^Jo( h(^Jo(h鰏ha85乗乛Jo( hd o( hd h猽)D,F,H,J,L,N,P,R,T, $d轧a$gd醨"#50P:p萭靶/ 班=!癝"癝#怱$7%靶靶 愋$J@J ck噀 $1$a$ CJKH_HaJmH nHsH tH$A$ 貫祂=刉[SOBiB nf恏樉_0S峡]旟胭U嘇趘鉸赜圻谪7aC狧澻妶vlq憙鶴2脉0a8沢9:長A6Et OpW聗_縤npr.s+uw.猽廭醨齏{nkq萭.(zj,鉣?鰏3@滠4* ````"UnknownS噝 Times New RomanTimes5Symbol3& 噝 Arial_ Times-RomanTimes New RomanyUniversal-NewswithCommPiTimes New Roman;媅SOSimSun"Ahs|靎s|靎j j $xx  3走?p.2j.fertnstert.2003.10user甠o(u7bh                  鄥燆鵒h珣+'迟0  < H T`hpxj.fertnstert.2003.10userNormal 微软用户2Microsoft Office Word@F#@汖=溗@汖=溗j 胀諟.摋+,0 X`px legend '   !"#$%&'()*+,-./0123456789;<=>?@ACDEFGHILRoot Entry F~i=溗N1TableS?WordDocument72SummaryInformation(:DocumentSummaryInformation8BCompObjm  FMicrosoft Office Word 文档 MSWordDocWord.Document.89瞦