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Background and objective: L-carnitine is an essential molecule involved in mitochondrial metabolism, controlling the transport of acetyl and acyl groups across the mitochondrial inner membrane. Carnitine and acetylated carnitine (L-acetylcarnitine) are found in high concentrations in the epididymis, where they also act as antioxidants, protecting spermatozoa against damage caused by reactive oxygen species. In this open study we investigated the correlation between seminal carnitine levels and spermatozoal f u n c t i o n , a n d t h e e f f e c t o f c o m b i n e d L - c a r n i t i n e + L - a c e t y l c a r n i t i n e t h e r a p y , i n i n f e r t i l e m e n .
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